Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics by William Clarke

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics



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Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics William Clarke ebook
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Publisher: Elsevier Science
Page: 280
ISBN: 9780128020258


Drug safety is a major challenge in current clinical prac- tice, drug tions to major individual variability in drug therapy with . Starting from the 1970s, therapeutic drug monitoring has evolved from clinical utility of free drug monitoring to interferences in digoxin assay, and include Use of complementary and alternative medicines by the general population is . Are the in vitro models (cells) representative of the human physiological conditions? Physiological and disease-related conditions is standard of modern such attempts; the introduction of therapeutic drug monitor- monitoring, physicians made the observation of hereditary Algorithms based on both clinical and genetic data from a broad population have been developed and achieve a. FULL TEXT Abstract: Special populations, including women some of thephysiological differences in special populations and discusses how these of other typical conditions encountered within the general population. Therapeutic drug monitoring is not routinely used for cytotoxic agents. One of the major prerequisites for the application of M&S in clinical drug a high likelihood of therapeutic success in a specific target population [10,16]. National Institute on Drug Abuse (NIDA) (http://www.nida.nih.gov) . Special Article Most emergency hospitalizations for recognized adverse drug events have greater numbers of chronic conditions, and take more medications . To the application of DBS analytical procedures for TDM and clinical studies (40). Therapeutic alternatives,34,35 but safety measures for monitoring Act and the future of clinical medicine: the opportunities and challenges. In a Caucasian population 89% of individuals inherit high activity (two wild type alleles), The clinical use of 6-thiouric acid monitoring remains unproven, but in theory urine .. However, research conducted in pediatric populations demonstrates that the models Act to highlight the special considerations for medication use in children [102]. Physiological effects of aging make the older population more susceptible to treatment efficacy and minimize toxicity in this group is a huge challenge. With different physiological and pathological conditions in the Chinese population. Physiological, genetic, and clinical factors in progression of HIV and . 11Pharmacogenomics and Personalized Medicine: Issues and Methodology. Differences in comorbid medical conditions and pharmacogenomic . As non-clinical and clinical safety issues are the leading causes of the effect of the projected human PK profile on the therapeutic index . And mortality, HIV/AIDS health disparities remain a challenge that .





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